« A MOST AMAZING CASE! | Main | Letters to the Editor in A and A Cite the Site and More »

AAGBI Establishes Guidelines for Treating LA Toxicity

The Association of Anaesthetists of Great Britain and Ireland has just sent all its members guidelines for the treatment of severe systemic local anesthetic toxicity. A laminated copy of these newly established, official guidelines was  sent to each of the roughly 10,000 members of the organization. This is groundbreaking in that there has never been a well-defined consensus for treating this life-threatening complication until now. The need for such an approach was brought to public attention by the recent survey of Corcoran et al from Wake Forest, and published this year in Anesthesia and Analgesia. They found that among respondant American academic Anesthesia departments that there was no agreement on an approach to treating severe local anesthetic toxicity. Furthermore, the study found a low rate of awareness or, at leat willingness, to consider using lipid in this setting. This may be because the survey was conducted prior to the case of Rosenblatt et al which reported the first use of lipid to save a patient's life following cardiac arrest in the setting of a regional anesthetic (bupivacaine + mepivacaine). Subsequently, several more case reports have been published and awareness is likely to have improved since the survey and the corresponding paper. Nevertheless, there is still a need for general guidelines and a uniform, rational method for treating this problem will significantly improve the liklihood of recovery from or prevent progression to, anesthetic-induced cardiac arrest. The AAGBI guidelines incorporate lipidrescue as a cornerstone of the treatment, refer to this site, reference laboratory investigations on lipidrescue and therefore add to the general acceptance of the technique. Notably, the recent letter of  Picard et al, elaborates on the parallels of this process to that for dantrolene in treatment of MH. The several additional case reports (published and in the literature pipeline) will further validate lipidresuce, and presumably strengthen its acceptance in the medical community. Congratulations to AAGBI. I strongly believe that their forward thinking action will contribute to improved patient safety and hopefully save lives, too.

Posted on Wednesday, August 22, 2007 at 09:11AM by Registered Commenter[Guy Weinberg] | Comments2 Comments

Reader Comments (2)

At the annual AACS (American Academy of Cosmetic Surgery) meeting this month, January, 2009, lipid rescue was introduced as a safety factor for Liposuction surgery. Many times, with tumescent liposuction, the maximum safe dose of lidocaine is used and potentially may achieve excessive blood levels if the metabolism of the lidocaine is compromized. It was suggested that a vial of Intralipid-20 be available on hand for any tumescent liposuction case to potentially prevent toxicity from happening.

The theory for using Intralipid is the it selectively absorbs the lidocaine and stores it in the intravascular space. Once sequestered, it would not produce toxic effects and would be then metabolized gradually over time by the liver.

Dr. Jeffrey Klein, the father of office based tumescent liposuction, reported this unique use of Intralipid at the conference. He called it the new antidote for lidocaine.

I thank Lipidrescue for providing a sounding board for this potentially lifesaving innovative new concept.

Robert L. True, MD, FACOG, AACS
Specializing in Cosmetics and Gynecology
January 26, 2009 | Unregistered CommenterRobert L True, MD
Hi Robert, thanks for the post. I'm very familiar with Dr. Klein's writings. He has been an important voice with respect to the risks of local anesthetic toxicity and I have the utmost respect for his work. I'm glad to hear he's helping to get the word out.
G.
January 26, 2009 | Registered Commenter[Guy Weinberg]

PostPost a New Comment

Enter your information below to add a new comment.

My response is on my own website »
Author Email (optional):
Author URL (optional):
Post:
 
All HTML will be escaped. Hyperlinks will be created for URLs automatically.