LipidRescue™ Resuscitation

Case Reports: Local Anesthetic Toxicity - Adult

• Dun-Chi Lin J, et al. Two for One: A Case Report of Intravenous Lipid Emulsion to Treat Local Anesthetic Systemic Toxicity in Term Pregnancy. A A Case Rep. 2017 Jan 17.
• Lynch W, et al. Lipid Emulsion Rescue of Amniotic Fluid Embolism-Induced Cardiac Arrest: A Case Report. A A Case Rep. 2016 Dec 9.
• Tierney KJ, Murano T, Natal B. Lidocaine-Induced Cardiac Arrest in the Emergency Department: Effectiveness of Lipid Therapy. J Emerg Med. 2016 Jan;50(1):47-50.
• Tsang TM, et al. Lipid rescue for treatment of delayed systemic ropivacaine toxicity from a continuous thoracic paravertebral block. BMJ Case Rep. 2016 Jun 14; 2016.
• Kamel I, Trehan G, Barnette R. Intralipid therapy for inadvertent peripheral nervous system blockade resulting from local anesthetic overdose. Case Rep Anesthesiol. 2015;2015:486543.
• Bazerbachi F, Rank K, Chan A. Intravenous lipid rescue and ropivacaine systemic toxicity. J Anesth. 2014 Feb;28(1):139.
• Arora NP, et al. Usefulness of intravenous lipid emulsion for cardiac toxicity from cocaine overdose. Am J Cardiol. 2013 Feb 1;111(3):445-7.
• Mazoit JX [Cardiac arrest and local anaesthetics]. [Article in French] Presse Med. 2013 Mar;42(3):280-6.
• Shih YH, et al. Successful reversal of bupivacaine and lidocaine-induced severe junctional bradycardia by lipid emulsion following infraclavicular brachial plexus block in a uremic patient. Acta Anaesthesiol Taiwan. 2011 Jun;49(2):72-4.
• Mizutani K, Oda Y, Sato H. Successful treatment of ropivacaine-induced central nervous system toxicity by use of lipid emulsion: effect on total and unbound plasma fractions. J Anesth. 2011 Jun;25(3):442-5. Epub 2011 Mar 16.
• Dix SK, et al. Intractable cardiac arrest due to lidocaine toxicity successfully resuscitated with lipid emulsion. Crit Care Med. 2011 Apr;39(4):872-4.
• Harvey M, et al. Successful resuscitation from bupivacaine-induced cardiovascular collapse with intravenous lipid emulsion following femoral nerve block in an emergency department. Emerg Med Australas. 2011 Apr;23(2):209-14.
• Benhamou D, et al. [Early administration of lipid rescue after initial signs of local anesthetic-induced systemic toxicity] [Article in French] Ann Fr Anesth Reanim. 2010 Nov;29(11):826. Epub 2010 Nov 3.
• Aveline, et al. Ineffectiveness of intralipid infusion for central nervous toxicity following ultrasound-guided sciatic nerve block with lidocaine-ropivacaine solution: interaction between carbamazepine, local anaesthetic and intralipid? Eur J Anaes 2010
• Uncles DR, Local anaesthetic systemic toxicity treated with intravenous lipid emulsion: ineffective treatment or selection of an inadequate lipid rescue dose? Eur J Anaesthesiol. 2011 May;28(5):390-1.
  A reply to Aveline C. et al, directly above
• Man D, Podichetty VK. Lipid rescue in resuscitation of local anesthetic-induced cardiac arrest in aesthetic surgery. Plast Reconstr Surg. 2010 Jun;125(6):257e-9e.
• Cordell CL, et al. Lipid infusion rescue for bupivacaine-induced cardiac arrest after axillary block. J Hand Surg Am. 2010 Jan;35(1):144-6.
• Wong GK, Joo DT, McDonnell C.Lipid resuscitation in a carnitine deficient child following intravascular migration of an epidural catheter*Anaesthesia. 2009 Oct 22.
• Marwick PC, Levin AI, Coetzee AR. Recurrence of cardiotoxicity after lipid rescue from bupivacaine-induced cardiac arrest. Anesth Analg. 2009 Apr;108(4):1344-6.
• McCutchen G, Gerancher JC. Early lipid therapy may have prevented bupivacaine-associated cardiac arrest. Reg Anesth Pain Med. 2008; 33(2):178-180
• Smith HM, Simulation education in anesthesia training: a case report of successful resuscitation of bupivacaine-induced cardiac arrest linked to recent simulation training. Anesth Analg. 2008 May;106(5):1581-4
• Warren JA, et al. Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block. Anesth Analg. 2008 May;106(5):1578-80
• Litz RJ, et al. Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection. Anesth Analg. 2008 May;106(5):1575-7
• Foxall G, et al. Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid. Anaesthesia. 2007 May;62(5):516-8.
• Zimmer C, et al. Cardiotoxic and neurotoxic effects after intravascular bupivacaine administration: therapy with lidocaine, propofol and lipid emulsion. Anaesthesist 2007
• Spence AG. Lipid reversal of central nervous system symptoms of bupivacaine toxicity. Anesthesiology. 2007 Sep;107(3):516-7
• Rosenblatt MA, et al. Successful Use of a 20% Lipid Emulsion to Resuscitate a Patient after a Presumed Bupivacaine-related Cardiac Arrest. Anesthesiology 2006;105:217-8.
• Litz RJ, et al. Successful resuscitation of a patient with ropivacaine-induced asystole after axillary plexus block using lipid infusion. Anaesthesia 2006;61:800-1.