• Older LipidRescue Experiments (rat) Showing Effects of Early and Late Treatment

    Arterial and ECG Traces of Actual Experiments
    • Lipid Given Early
      In this experiment, a 4 mL/kg bolus of 20% lipid was given approximately one minute after bupivacaine induced asystole (15 mg/kg bupivacaine given iv over 30 sec). The lipid bolus was repeated once approximately 5 minutes later and an infusion started.
    • Lipid Given Late (20 minutes downtime)
      A control experiment, converted after 20 min unsuccessful resuscitation to a lipid treatment.

  • Newer LipidRescue Experiments Comparing Lipid with Saline and "No-Treatment' 

    This is a group of three experiments on anesthetized rats. Each recieves a large bolus of bupivacaine, then in addition to ventilation with 100% oxygen and chest compressions are given one of three iv treatments: nothing, saline or lipid emulsion.  
    • No Intravenous Treatment
      There is minimal recovery of hemodynamics over several minutes of resuscitation. This is a 'no-treatment' control. Note the audio commentary.
    • Saline Treatment
      This experiment controls for the effects of volume on recovery from bupivacaine overdose. There is minimal hemodynamic recovery.
    • LipidRescue
      This subject received lipid emulsion in addition to chest compressions and ventilation with 100% oxygen. Recovery is complete by four minutes. Note the audio commentary.