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LipidRescue™ Resuscitation

20% lipid emulsion for rescue from drug toxicity
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IN AN EMERGENCY:
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  • Welcome
  • Background
  • Treatment Overview
  • Medical Literature
    • Case Reports
      • Local Anesthetic Toxicity - Adult
      • Local Anesthetic Toxicity -Pediatric
      • Non-Local Anesthetic Toxicity
      • Veterinary
    • Laboratory Studies
      • Local Anesthetic Toxicity
      • Non-Local Anesthetic Toxicity
      • Mechanisms
    • Clinical Studies
    • Reviews
    • Surveys and Registries
    • Editorials
    • Guidelines and Recommendations
    • Miscellaneous
  • Local Anesthetic Toxicity
    • Overview
    • Epidemiology
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  • LipidRescue for Your Facility
  • Instructions (PDFs)
  • Sample LipidRescue™ Kit
  • LipidRescue™ Experiments (Videos)
  • Weinberg Bio
  • Registry Proposal
  • Ask Us
  • An important request for all LipidRescuers
  • Professional Connections
    Places of interest
    • University of Illinois at Chicago Department of Anesthesiology
      This has been my professional home for 20 years.
    • The Journal of Anesthesiology
    • NYSORA: The NY School of Regional Anesthesia
    • The American Society of Regional Anesthesia
    • Regional Anesthesia and Pain Medicine
      The official publication of ASRA
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A Review of Lipid Resuscitation
  • A Comprehensive Review of Lipid Resuscitation
  • Research (Bupivacaine Cardiac Preservation)
  • Clinical Studies

    • Mithani S, et al. A cohort study of unstable overdose patients treated with intravenous lipid emulsion therapy. CJEM. 2016 Nov 23:1-9. [Epub ahead of print]
    • Dureau P, et al. Effect of Intralipid® on the Dose of Ropivacaine or Levobupivacaine Tolerated by Volunteers: A Clinical and Pharmacokinetic Study. Anesthesiology. 2016 Sep;125(3):474-83.
    • Xu M, et al. Regional anesthesia and lipid resuscitation for local anesthetic systemic toxicity in China... BMC Anesthesiol. 2016 Jan 4;16:1.
    • Sebe A, et al. Role of intravenous lipid emulsions in the management of calcium channel blocker and β-blocker overdose: 3 years experience of a university hospital. Postgrad Med. 2015 Mar;127(2):119-24.
    • Sagir A, Goyal R. An assessment of the awareness of local anesthetic systemic toxicity among multi-specialty postgraduate residents. J Anesth. 2015 Apr;29(2):299-302.
    • Heinonen JA, et al. Incidence of severe local anaesthetic toxicity and adoption of lipid rescue in Finnish anaesthesia departments in 2011-2013. Acta Anaesthesiol Scand. 2015 Sep;59(8):1032-7.
    • Lee HM, et al. What are the adverse effects associated with the combined use of intravenous lipid emulsion and extracorporeal membrane oxygenation in the poisoned patient? Clin Toxicol (Phila). 2015 Mar;53(3):145-50.
    • Peacock RE, et al, A randomized, controlled clinical trial of intravenous lipid emulsion as an adjunctive treatment for permethrin toxicosis in cats. J Vet Emerg Crit Care. 2015
    • Cave G, et al. LIPAEMIC report: results of clinical use of intravenous lipid emulsion in drug toxicity reported to an online lipid registry. J Med Toxicol. 2014 Jun;10(2):133-42.
    • Eren Cevik S, et al. Intralipid emulsion treatment as an antidote in lipophilic drug intoxications. Am J Emerg Med. 2014 Sep;32(9):1103-8.
    • Gil HW, et al. Effect of intravenous lipid emulsion in patients with acute glyphosate intoxication. Clin Toxicol (Phila). 2013 Sep-Oct;51(8):767-71.
    • Toledo P, et al. Brief report: Availability of lipid emulsion in United States obstetric units. Anesth Analg. 2013 Feb;116(2):406-8.
    • Presley JD, Chyka PA. Intravenous lipid emulsion to reverse acute drug toxicity in pediatric patients. Ann Pharmacother. 2013 May;47(5):735-43.
    • Moon HJ, Lee JW. Availability of intravenous lipid emulsion therapy on endosulfan-induced cardiovascular collapse. Am J Emerg Med. 2013 May;31(5):886.e1-2.
    • Taftachi F, et al. Lipid emulsion improves Glasgow Coma Scale and decreases blood glucose level in the setting of acute non-local anesthetic drug poisoning - A randomized controlled trial. Eur Rev Med Pharmacol Sci. 2012;16(Suppl 1):38-42.
    • Jensen-Gadegaard P, et al. Limited knowledge of lipid rescue therapy in local anaesthetic systemic toxicity. Dan Med Bull 2011 Jan; 58(1): A4226
    • Picard J, et al. Guidelines and the adoption of 'lipid rescue' therapy for local anaesthetic toxicity. Anaesthesia. 2009 Feb;64(2):122-5.
    • Picard J, et al. Guidelines and the adoption of 'lipid rescue' therapy for local anaesthetic toxicity. Anaesthesia. 2009 Feb;64(2):122-5
    • Cave G, Harvey M. Intravenous lipid emulsion as antidote beyond local anesthetic toxicity: a systematic review. Anesthesiology. 2009 Sep;111(3):498-505.
    • Harvey M, Cave G. Survey of the availability of lipid emulsion infusion in Australasian emergency departments. Emerg Med Australas. 2008 Dec;20(6):531-3.
    • Williamson RM, Haines J.Availability of lipid emulsion in obstetric anaesthesia in the UK: a national questionnaire survey. Anaesthesia. 2008 Apr;63(4):385-8
    • Corcoran W, et al. Local anesthetic-induced cardiac toxicity: a survey of contemporary practice strategies among academic anesthesiology departments. Anesth Analg. 2006 Nov;103(5):1322-6.
Copyright © 2012, Guy Weinberg, MD. All rights reserved.