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LipidRescue™ Resuscitation
20% lipid emulsion for rescue from drug toxicity
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Local Anesthetic Toxicity - Adult
Local Anesthetic Toxicity -Pediatric
Non-Local Anesthetic Toxicity
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Local Anesthetic Toxicity
Non-Local Anesthetic Toxicity
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Local Anesthetic Toxicity
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University of Illinois at Chicago Department of Anesthesiology
This has been my professional home for 20 years.
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A Review of Lipid Resuscitation
A Comprehensive Review of Lipid Resuscitation
Research (Bupivacaine Cardiac Preservation)
Editorials
Tucker GT. Physiologically based pharmacokinetic-pharmacodynamic modeling to the rescue: understanding how resuscitation from local anesthetic overdose with lipid emulsions works. Anesthesiology. 2014 Apr;120(4):795-6.
Zausig YA, Zink W, Graf BM. Lipophilicity of local anesthetics and success of lipid emulsion therapy. Crit Care Med. 2012 Jan;40(1):359-60.
Killoran PV, Cattano D. From bedside to bench and back: perfecting lipid emulsion therapy for local anesthetic toxicity. Anesthesiology. 2011 Dec;115(6):1151-2.
Weinberg G, Rubinstein I. Pig in a Poke: Species Specificity in Modeling Lipid Resuscitation. Anesth Analg. 2011 Dec 20. [Epub ahead of print]
Kawaraguchi Y, Roth DM, Patel HH. From Local to Global: Intralipid Makes a Move. Anesthesiology. 2011 Jun 8. [Epub ahead of print]
Uncles DR, et al. Local anaesthetic systemic toxicity treated with intravenous lipid emulsion: ineffective treatment or selection of an inadequate lipid rescue dose? Eur J Anaesthesiol. 2011 May;28(5):390-1.
Weinberg GL. Intravenous lipid emulsion: why wait to save a life? Emerg Med Australas. 2011 Apr;23(2):113-5.
Cave G, Harvey M. Intravenous lipid emulsion as antidote: How should we chew the fat in 2011? Crit Care Med 2011 Apr; 39(4): 919-20.
Murray DB, Bateman DN.Use of intravenous lipids. Not yet in all overdoses with failed resuscitation. BMJ. 2011 Apr 8;342:d2265.
Samuels TL, et al. Logging the potential for intravenous lipid emulsion in propranolol and other lipophilic drug overdoses. Anaesthesia. 2011 Mar;66(3):221-2.
Davis W. Factors related to recovery in a cat treated for lidocaine intoxication. J Am Vet Med Assoc. 2011 Feb 1;238(3):284; author reply 284.
Weinberg G, et al. Partitioning effect in lipid resuscitation: further evidence for the lipid sink. Crit Care Med. 2010 Nov;38(11):2268-9.
Woehlck HJ, El-Orbany M. Anesthetic effects and lipid resuscitation protocols. Anesthesiology. 2010 Feb;112(2):499-500
McKevith J, Banks A. Lipid resuscitation. Resuscitation. 2009 Dec;80(12):1448. Epub 2009 Oct 4.
Isherwood P. Lipid rescue: small trials and animal research. Anaesthesia. 2009 Dec;64(12):1380
Cave G, Harvey M. Intravenous lipid emulsion as antidote beyond local anesthetic toxicity: a systematic review. Anesthesiology. 2009 Sep;111(3):498-505.
Picard J, Harrop-Griffiths W. Lipid emulsion to treat drug overdose: past, present and future. Anaesthesia. 2009 Feb;64(2):119-21.
Picard J, Ward S, Meek T. Antidotes to anesthetic catastrophe: lipid emulsion and dantrolene. Anesth Analg. 2007 Jul;105(1):283-4
Brull SJ. Lipid emulsion for the treatment of local anesthetic toxicity: patient safety implications. Anesth Analg. 2008 May;106(5):1337-9
Rowlingson JC. Lipid rescue: a step forward in patient safety? Likely so! Anesth Analg. 2008 May;106(5):1333-6
Weinberg GL. Lipid infusion therapy: translation to clinical practice. Anesth Analg. 2008 May;106(5):1340-2
Picard J, Meek T. Lipid emulsion to treat overdose of local anaesthetic: the gift of the glob. Anaesthesia 2006;61:107-9.
Weinberg G. Lipid infusion resuscitation for local anesthetic toxicity: proof of clinical efficacy. Anesthesiology 2006;105:7-8.
Groban L, Butterworth J. Lipid reversal of bupivacaine toxicity: has the silver bullet been identified? Reg Anesth Pain Med 2003;28:167-9.
Copyright © 2012, Guy Weinberg, MD. All rights reserved.