Ask Us > lipid rescue for ropivicaine toxicity (No good for Pigs!)

The Australian College of Anaesthetists posted this abstract
on it's website following the 2009 Annual Scientific meeting:

http://www.anzca.edu.au/events/asm/asm2009/abstracts/lipid-emulsion-infusion-vs-standard-cardiac.html

This suggests lipid rescue may not be effective for ropivicaine induced toxicity. Is there other studies to support/ refute this?
September 24, 2010 | Unregistered CommenterDr Paul Oo
I would need to see all the data, Dr. Oo to form an opinion but the fact that clinial reports have shown efficacy of lipid rescue in resuscitating patients with severe ropivacaine toxicity suggests that the experimental design used in this abstract may not be a good model of clinical toxicity and its treatment in humans. Notably, I don't believe systolic pressure at one time is a good endpoint. It sort of guarantees success of epinphrine treatment which will generally provide early recovery of systolic pressure with subsequent decline. I wonder if measurements at 20-30 minutes without further adrenergic support would have continued to show recovery by their criteria.
September 27, 2010 | Registered Commenter[Guy Weinberg]