Ask Us > Use of ClinOleic or other refined olive oil based lipid emulsion

From what I have seen, INTRALIPID 20% has been used most commonly in treating drug toxicities. Has anyone used or seen any data with using ClinOleic 20% lipid emulsion for infusion (=a mixture of ~ 80% refined olive oil and ~20% refined soybean oil?
September 10, 2012 | Unregistered CommenterJenny, RPh
Abstract
During general anesthesia and intensive care applications that require control
of the airway respiratory, cardiovascular reflex responses occur thus myocardial
oxygen delivery and consumption can be negatively affected. To prevent these
effects, lidocaine, opioids, magnesium, calcium channel blockers, beta-blockers
have been used. Local anesthetic toxicity; is usually known to occur when used
over the range of safe dose of local anesthetics. It has been shown in a variety of
animal and clinical studies that a lipid emulsion used for parenteral nutrition improves
resistance to fatal cardiac effects caused by local anesthetics. Herein, we
presented a case who had developed sudden bradycardia, asystole by iv. lidocaine
which is used for tracheal intubation and improved dramatically after treatment
with lipid emulsion in the light of the literatures. According to our knowledge it is
the first case which is succesfully resuciatated with clinoleic in local anesthetic
toxicity in literature.
Keywords
Lidocaine Toxicity; Emergency Intubation; Clinoleic; Lipid Emulsion Treatment
Journal of Clinical and Analytical Medicine
Lidokain Toksisitesi / Toxicity of Lidocaine
Toxicity of Lidocaine Improved with Lipid Emulsion Treatment:
Case Report
DOI: 10.4328/JCAM.1572 Received: 23.01.2013 Accepted: 11.02.2013 Publihed Online: 11.02.2013
Corresponding Author: Edip Gönüllü, Van Bölge Eğitim ve Araştırma Hastanesi, Anestezi ve Reanimasyon Kliniği, Van, Türkiye.
T.: +905057672488 E-Mail: edipgonullu@gmail.com
Journal of Clinical and Analytical Medicine
February 24, 2013 | Unregistered Commenteredip gönüllü