Ask Us > Lipid solubility resource
Hi Jason. Feel free to tell us more about your case...that won't preclude your writing it up for peer-review publication. Meantime, there are at least three options for finding this information:
1. Block and Beale, Wilson and Givold's Organic Medicinal and Pharmacutical Chemistry. Appendix.
2. Chemspider.com
3. Google
if you're looking specifically for benedryl, logP = 3.66; logD (pH7) = 1.92; pKa (BH+) = 8.76
1. Block and Beale, Wilson and Givold's Organic Medicinal and Pharmacutical Chemistry. Appendix.
2. Chemspider.com
3. Google
if you're looking specifically for benedryl, logP = 3.66; logD (pH7) = 1.92; pKa (BH+) = 8.76
December 4, 2012 |
[Guy Weinberg]
[Guy Weinberg]
I am preparing a case report for publication regarding treatment of a diphenhydramine overdose using lipid emulsion. I am attempting to find a user-friendly resource for determining the pKa/lipophilicity of drugs at physiologic pH. Any suggestions?
Thanks!