Ask Us > Cocaine induced arrhythmia
Great question Sylva. The short answer is, "we don't know". The reason it might not work is not related to cocaine being an ester. It's because it's not so lipophilic as bupivacaine. however, it does inhibit the same metabolic steps in fatty acid metabolism as does bupivacaine and one could argue that it might work. We did some preliminary studies a while back that showed lipid pretreatment does reduce cocaaine toxicity. However, further studies are needed. Meantime, I can't imagine that it isn't worth a try....assuming that the patient is well oxygenated.
Good luck and thanks for the question
Good luck and thanks for the question
September 15, 2008 |
[Guy Weinberg]
[Guy Weinberg]
In our case, we did not use it, as cocaine is not an amide LA and the effects of Intralipid in this case were not known to us.