Ask Us > Lipophilicity of drugs

With lipid rescue moving into the relm of toxic ingestions, what is the best source for determining the lipophilicity of a drug?
December 9, 2008 | Unregistered CommenterJR
That is a GREAT question - very important because we all want to have a rapid reference for drug lipid solubilities close at hand....i'm not kidding. I recommend
Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry, 11th edition, editors: John Block and John Beale, Jr.
This is a SUPERB reference. and the appendix (p 948) has several hundred drugs listed by log P, log D and pKa. So, for instance, you can see that three drugs with clinical reports of lipidrescue success, bupivacaine (logP 3.64), bupropion (logP3.47) and haloperidol (logP4.06) all have very high octanol:water partition coefficients.
I recommend you get this book.
Thanks for the great question
Guy
December 12, 2008 | Registered Commenter[Guy Weinberg]