Ask Us > Lipid Rescue for Feline Permethrin Toxicity?

Hello. I'm a senior veterinary student at Michigan State and had a question about efficacy of lipid rescue in permethrin toxicity.

I have had the opportunity to see lipid rescue utilized successfully at MSU and the Tufts vet school in cases of canine and feline ivermectin and moxidectin toxicity.

I was wondering what your opinion might be on using lipid rescue as a treatment for cats with permethrin toxicity (a common toxicity when canine flea products are applied to cats).

I've had little success determing exactly how lipophilic pyrethroids/permethrins are. The links below show support for the lipophilic nature of these compounds.

Anyways, I would appreciate any input/opinions that anyone may have.

Thank you very much for your time.

Matthew Holahan
MSU CVM 2009


1)
http://boardtalk.vpb.nsw.gov.au/index.php?h=ShowArticleItem&issue_id=52&article_id=11


2)
http://www.bioone.org/doi/full/10.1603/0046-225X%282001%29030%5B0070%3AAOPCAT%5D2.0.CO%3B2

Under first paragraph of the discussion:
Quote:
"Permethrin and esfenvalerate are particularly suited for surface area analysis due to their relative lipophilicity"
February 7, 2009 | Unregistered CommenterMatt Holahan
Hi Matt,
I just look at the Appendix in my trusty Wilson and Gisvold's Textbook of Organic, Medicinal and Pharmaceutical Chemistry. Permethrin has a logP ~6, which makes it highly lipophilic (more lipid soluble than bupivacaine). So my prediction is that permetrhin toxicity should be treatable by lipidrescue. Good luck. I look forward to reading your first case report...just send me the reference after it's accepted.
Regards,
Guy
February 8, 2009 | Unregistered Commenter[Guy Weinberg]
Guy,

Thank you very much for that info. I've got a couple months left of school before I head out into "the real world" but I will definitely look for any/all opportunities to pursue this and will keep you apprised.

Thanks,
matt
February 8, 2009 | Unregistered CommenterMatt Holahan