LipidRescue™ Resuscitation

Laboratory Studies: Non-Local Anesthetic Toxicity

• Akgün Şahin F, et al. Therapeutic effects of intralipid and medialipid emulsionsin a rat model of verapamil toxicity. Turk J Med Sci. 2016 Nov 17;46(5):1568-1572.
• Murphy CM, et al. Pilot Trial of Intravenous Lipid Emulsion Treatment for Severe Nifedipine-Induced Shock. J Med Toxicol. 2016 Dec;12(4):380-385
• Ozsoy AZ, et al. Protective effect of intravenous lipid emulsion treatment on malathion-induced ovarian toxicity in female rats. Eur Rev Med Pharmacol Sci. 2016 Jun
• Xanthos T, et al. Intralipid™ administration attenuates the hypotensive effects of acute intravenous amiodarone overdose in a swine model. Am J Emerg Med. 2016 Aug;34(8):1389-93.
• Yurtlu BS, et al. Intravenous lipid emulsion prolongs survival in rats intoxicated with digoxin. Am J Emerg Med. 2016 Jun;34(6):1112-6.
• Tulgar S, et al. Comparison of Effects of Separate and Combined Sugammadex and Lipid Emulsion Administration on Hemodynamic Parameters and Survival in a Rat Model of Verapamil Toxicity. Med Sci Monit. 2016 Mar 25;22:984-90.
• Udelsmann A, Melo Mde S. Hemodynamic changes with high infusion rates of lipid emulsion. Experimental study in swine. Acta Cir Bras. 2015 Nov;30(11):720-6.
• Varney SM, et al. Intravenous Lipid Emulsion Therapy for Severe Diphenhydramine Toxicity: A Randomized, Controlled Pilot Study in a Swine Model. Ann Emerg Med. 2016 Feb;67(2):196-205.e3.
• Varney SM, et al. Intravenous Lipid Emulsion Therapy for Severe Diphenhydramine Toxicity: A Randomized, Controlled Pilot Study in a Swine Model. Ann Emerg Med. 2016 Feb;67(2):196-205.e3.
• Kang C, et al. The effects of intravenous lipid emulsion on prolongation of survival in a rat model of calcium channel blocker toxicity. Clin Toxicol (Phila). 2015 Jul;53(6):540-4.
• Fettiplace MR, et al. Cardiac depression induced by cocaine or cocaethylene is alleviated by lipid emulsion more effectively than by sulfobutylether-β-cyclodextrin. Acad Emerg Med. 2015 May;22(5):508-17.
• Lou PH, et al. Propofol (Diprivan®) and Intralipid® exacerbate insulin resistance in type-2 diabetic hearts by impairing GLUT4 trafficking. Anesth Analg. 2015 Feb;120(2):329-40.
• Peacock RE, et al. A randomized, controlled clinical trial of intravenous lipid emulsion as an adjunctive treatment for permethrin toxicosis in cats. J Vet Emerg Crit Care. 2015
• Bedocs P, et al. Hypersensitivity reactions to intravenous lipid emulsion in swine: relevance for lipid resuscitation studies. Anesth Analg. 2014 Nov;119(5):1094-101.
• Moshiri M, et al. Failure of Intravenous Lipid Emulsion to Reduce Diazinon-induced Acute Toxicity: a Pilot Study in Rats. Iran J Pharm Res. 2013 Fall;12(4):897-902.
• Moshiri M, et al. Evaluation of intravenous lipid emulsion on haloperidol-induced hypotension in rabbits. Toxicol Ind Health. 2016 May;32(5):945-52.
• Harvey M, Cave G, Ong B. Intravenous lipid emulsion-augmented plasma exchange in a rabbit model of clomipramine toxicity; survival, but no sink. Clin Toxicol (Phila). 2014 Jan;52(1):13-9.
• Carreiro S, Blum J, Hack JB. Pretreatment with intravenous lipid emulsion reduces mortality from cocaine toxicity in a rat model. Ann Emerg Med. 2014 Jul;64(1):32-7.
• Von Der Wellen J, et al. Investigations of kinetic interactions between lipid emulsions, hydroxyethyl starch or dextran and organophosphorus compounds. Clin Toxicol (Phila). 2013 Dec;51(10):918-22.
• Tuzcu K, et al. Oral intralipid emulsion use: a novel therapeutic approach to pancreatic β-cell injury caused by malathion toxicity in rats. Drug Chem Toxicol. 2014 Jul;37(3):261-7.
• Cave G, et al. Comparison of intravenous lipid emulsion, bicarbonate, and tailored liposomes in rabbit clomipramine toxicity. Acad Emerg Med. 2013 Oct;20(10):1076-9
• Vahabzadeh M, et al. Promising effects of intravenous lipid emulsion as an antidote in acute tramadol poisoning. Reg Anesth Pain Med. 2013 Sep-Oct;38(5):425-30.
• Li Y, et al. Development of intravenous lipid emulsion of vinorelbine based on drug-phospholipid complex technique. Int J Pharm. 2013 Sep 15;454(1):472-7.
• Cave G, Harvey M, Quinn P, Heys D. Hypertonic sodium bicarbonate versus intravenous lipid emulsion in a rabbit model of intravenous flecainide toxicity: no difference, no sink. Clin Toxicol (Phila). 2013 Jun;51(5):394-7.
• Heinonen JA, et al. Intravenous lipid emulsion entraps amitriptyline into plasma and can lower its brain concentration--an experimental intoxication study in pigs. Basic Clin Pharmacol Toxicol. 2013 Sep;113(3):193-200.
• Ma WC, et al. Development of intravenous lipid emulsion of α-asarone with significantly improved safety and enhanced efficacy. Int J Pharm. 2013 Jun 25;450(1-2):21-30.
• Fettiplace MR, et al. Rapid cardiotonic effects of lipid emulsion infusion*. Crit Care Med. 2013 Aug;41(8):e156-62.
• Wong GT, Irwin MG. Poisoning with illicit substances: toxicology for the anaesthetist. Anaesthesia. 2013 Jan;68 Suppl 1:117-24.
• Rahman S, et al. Phosphorylation of GSK-3β Mediates Intralipid-induced Cardioprotection against Ischemia/Reperfusion Injury. Anesthesiology. 2011 Jun 17. [Epub ahead of print]
• Harvey M, et al. Insulin versus Lipid Emulsion in a Rabbit Model of Severe Propranolol Toxicity: A Pilot Study. Crit Care Res Pract. 2011;2011:361737. Epub 2011 Mar 31
• Samuels TL, et al. Logging the potential for intravenous lipid emulsion in propranolol and other lipophilic drug overdoses. Anaesthesia. 2011 Mar;66(3):221-2.
• Kazemi A, et al. The effect of lipid emulsion on depth of anaesthesia following thiopental administration to rabbits. Anaesthesia. 2011 May;66(5):373-8.
• Lokajová J, In vitro capturing of various lipophilic illicit drugs by lipid dispersions. An electrokinetic capillary chromatography and fluorescence polarization study. Eur J Pharm Sci. 2010 Nov 20;41(3-4):515-22
• Zhou Y, et al, Intravenous lipid emulsions combine extracorporeal blood purification: a novel therapeutic strategy for severe organophosphate poisoning. Med Hypotheses. 2010 Feb;74(2):309-11. Epub 2009 Sep 27.
• Harvey M, Cave G, Kazemi A. Intralipid infusion diminishes return of spontaneous circulation after hypoxic cardiac arrest in rabbits. Anesth Analg. 2009 Apr;108(4):1163-8.
• Perez E, et al. Determining the Optimal Dose of Intravenous Fat Emulsion for the Treatment of Severe Verapamil Toxicity in a Rodent Model. Acad Emerg Med. 2008 Oct 25. [Epub ahead of print]
• Bania T, et al. Hemodynamic effects of intravenous fat emulsion in an animal model of verapamil toxicity resuscitated with atropine, calcium and saline. Acad. Emerg. Med. 2007; 14:105-11
• Harvey M, Cave G. Intralipid Outperforms Sodium Bicarbonate in a Rabbit Model of Clomipramine Toxicity. Ann Emerg Med. 2006 Nov 9; [Epub ahead of print]