LipidRescue™ Resuscitation

Laboratory Studies: Mechanisms

• Fettiplace M, et al. Insulin signaling in bupivacaine-induced cardiac toxicity: Sensitization during recovery and potentiation by lipid emulsion. Anesthesiology 2016; 124: 428-42
• Dureau P, et al. Effect of Intralipid® on the Dose of Ropivacaine or Levobupivacaine Tolerated by Volunteers: A Clinical and Pharmacokinetic Study. Anesthesiology. 2016 Sep;125(3):474-83.
• Fettiplace MR, et al. Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion. Anesthesiology 2016; 124: 428-42
• Fettiplace MR, et al. Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion. J Control Release 2015; 198: 62-70
• Fettiplace M, et al. Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride microemulsion. J Controlled Release, 2015; 198: 62-70.
• Fettiplace MR, et al. Resuscitation with lipid emulsion: dose-dependent recovery from cardiac pharmacotoxicity requires a cardiotonic effect. Anesthesiology 2014; 120: 915-25
• Li J, et al. Lipid emulsion rapidly restores contractility in stunned mouse cardiomyocytes: a comparison with therapeutic hypothermia. Crit Care Med 2014; 42: e734-40
• Shi K, et al. The effect of lipid emulsion on pharmacokinetics and tissue distribution of bupivacaine in rats. Anesth Analg. 2013 Apr;116(4):804-9.
• Kuo I, Akpa BS. Validity of the lipid sink as a mechanism for the reversal of local anesthetic systemic toxicity: a physiologically based pharmacokinetic model study. Anesthesiology. 2013 Jun;118(6):1350-61.
• Litonius E, et al. Effect of intravenous lipid emulsion on bupivacaine plasma concentration in humans. Anaesthesia 2012; 67: 600-5
• Rahman S, et al. Phosphorylation of GSK-3β Mediates Intralipid-induced Cardioprotection against Ischemia/Reperfusion Injury. Anesthesiology. 2011 Jun 17. [Epub ahead of print]
• Weinberg G, et al. Partitioning effect in lipid resuscitation: further evidence for the lipid sink. Critical Care Medicine 2010; 38: 2268-9.