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LipidRescue™ Resuscitation

20% lipid emulsion for rescue from drug toxicity
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IN AN EMERGENCY:
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  • Welcome
  • Background
  • Treatment Overview
  • Medical Literature
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      • Local Anesthetic Toxicity - Adult
      • Local Anesthetic Toxicity -Pediatric
      • Non-Local Anesthetic Toxicity
      • Veterinary
    • Laboratory Studies
      • Local Anesthetic Toxicity
      • Non-Local Anesthetic Toxicity
      • Mechanisms
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  • Local Anesthetic Toxicity
    • Overview
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  • An important request for all LipidRescuers
  • Professional Connections
    Places of interest
    • University of Illinois at Chicago Department of Anesthesiology
      This has been my professional home for 20 years.
    • The Journal of Anesthesiology
    • NYSORA: The NY School of Regional Anesthesia
    • The American Society of Regional Anesthesia
    • Regional Anesthesia and Pain Medicine
      The official publication of ASRA
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A Review of Lipid Resuscitation
  • A Comprehensive Review of Lipid Resuscitation
  • Research (Bupivacaine Cardiac Preservation)
  • Reviews

    • Muller SH, Diaz JH, Kaye AD. Intralipid Emulsion Rescue Therapy: Emerging Therapeutic Indications in Medical Practice. J La State Med Soc. 2016 May-Jun;168(3):101-3.
    • Hayes BD, et al. Systematic review of clinical adverse events reported after acute intravenous lipid emulsion administration. Clin Toxicol (Phila). 2016 Jun;54(5):365-404.
    • Hoegberg LC, et al. Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity. Clin Toxicol (Phila). 2016 Mar;54(3):167-93
    • Levine M, et al. Lipid Emulsion Workgroup. Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity. Clin Toxicol (Phila). 2016 Mar;54(3):194-221.
    • Grunbaum AM, et al. Review of the effect of intravenous lipid emulsion on laboratory analyses. Clin Toxicol (Phila). 2016;54(2):92-102. doi: 10.3109/15563650.2015.1115515. Epub 2015 Dec 1.
    • Vasques F, et al. A Review of Local Anesthetic Systemic Toxicity Cases Since Publication of the American Society of Regional Anesthesia Recommendations: To Whom It May Concern. Reg Anesth Pain Med. 2015 Nov-Dec;40(6):698-705.
    • Collins S, et al. Lipid Emulsion in Treatment of Local Anesthetic Toxicity. J Perianesth Nurs. 2015 Aug;30(4):308-20.
    • Fettiplace MR, et al. Past, Present, and Future of Lipid Resuscitation Therapy. JPEN J Parenter Enteral Nutr. 2015 Sep;39(1 Suppl):72S-83S.
    • Damitz R, Chauhan A. Parenteral emulsions and liposomes to treat drug overdose. Adv Drug Deliv Rev. 2015 Aug 1;90:12-23.
    • Gosselin S, et al. Methodology for AACT evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning. Clin Toxicol (Phila). 2015 Jul;53(6):557-64.
    • Muller SH, Diaz JH, Kaye AD. Clinical applications of intravenous lipid emulsion therapy. J Anesth. 2015 Dec;29(6):920-6.
    • Cao D, et al. Intravenous lipid emulsion in the emergency department: a systematic review of recent literature. J Emerg Med. 2015 Mar;48(3):387-97.
    • Dickerson DM, Apfelbaum JL. Local anesthetic systemic toxicity. Aesthet Surg J. 2014 Sep;34(7):1111-9.
    • Nouette-Gaulain K, et al. [Intravenous lipid emulsion and local anesthetic-induced systemic toxicity: mechanisms and limits] [Article in French] Ann Fr Anesth Reanim. 2014 Jun;33(6):411-7
    • Levine M, et al. Complications following antidotal use of intravenous lipid emulsion therapy. J Med Toxicol. 2014 Mar;10(1):10-4.
    • Tian H, et al. Safety and efficacy of a new parenteral lipid emulsion (SMOF) for surgical patients: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2013 Dec;71(12):815-21.
    • Groszek B. [Intravenous fat emulsions in toxicology]. [Article in Polish] Przegl Lek. 2012;69(8):477-82.
    • Mercado P, Weinberg GL. Local anesthetic systemic toxicity: prevention and treatment. Anesthesiol Clin. 2011 Jun;29(2):233-4
    • Ciechanowicz S, Patil V. Lipid emulsion for local anesthetic systemic toxicity. Anesthesiol Res Pract. 2012;2012:131784. Epub 2011 Sep 29
    • Fernandez, A et al. The use of intravenous lipid emulsion as an antidote in veterinary toxicology. J Vet Emerg Crit Care. 2011 June 3.
    • Cave G, Harvey M, Graudins A. Intravenous lipid emulsion as antidote: a summary of published human experience. Emerg Med Australas. 2011 Apr;23(2):123-41
    • Bern S, Weinberg G. Local anesthetic toxicity and lipid resuscitation in pregnancy. Curr Opin Anaesthesiol. 2011 Apr 13.
    • Bern S, et al. Lipid resuscitation: a life-saving antidote for local anesthetic toxicity. Curr Pharm Biotechnol. 2011 Feb 1;12(2):313-9.
    • Skjønnemand M, et al. [Intravenous administration of lipids in poisoning caused by local analgesics] [Article in Danish] Ugeskr Laeger. 2011 Jan 10;173(2):120-3.
    • Toledo P. The role of lipid emulsion during advanced cardiac life support for local anesthetic toxicity.J Obstet Anesth. 2011 Jan;20(1):60-3. Epub 2010 Nov 26.
    • Burch MS, et al. Treatment of local-anesthetic toxicity with lipid emulsion therapy. Am J Health Syst Pharm. 2011 Jan 15;68(2):125-9.
    • Sandlin-Leming DC. Resuscitation of local anesthesia-induced cardiac arrest: lipids to the rescue. J Perianesth Nurs. 2010 Dec;25(6):418-20.
    • Lui KC, Chow YF. Safe use of local anaesthetics: prevention and management of systemic toxicity. Hong Kong Med J. 2010 Dec;16(6):470-5
    • Rothschild L, et al. Intravenous lipid emulsion in clinical toxicology. Scand J Trauma Resusc Emerg Med. 2010 Oct 5;18:51.
    • Dillane D, Finucane BT.Local anesthetic systemic toxicity. Can J Anaesth. 2010 Apr;57(4):368-80
    • Bourne E, Wright C, Royse C. A review of local anesthetic cardiotoxicity and treatment with lipid emulsion. Local and Regional Anesthesia. Feb 2010:3 11-19
    • Jamaty C, et al. Lipid emulsions in the treatment of acute poisoning: a systematic review of human and animal studies. Clin Toxicol (Phila). 2010 Jan;48(1):1-27.
    • Leskiw U, Weinberg GL.Lipid resuscitation for local anesthetic toxicity: is it really lifesaving? Curr Opin Anaesthesiol. 2009 Oct;22(5):667-71
    • Cave G, Harvey M. Intravenous lipid emulsion as antidote beyond local anesthetic toxicity: a systematic review. Anesthesiology. 2009 Sep;111(3):498-505.
    • Weinberg, G. Lipid Rescue Resuscitation from Local Anaesthetic Cardiac Toxicity. Toxicological Reviews, Volume 25, Number 3, 2006, pp. 139-145(7)
    • Guy L Weinberg, Malek G Massad, Metabolic modulation for cardiac protection.Expert Review of Cardiovascular Therapy, March 2007, Vol. 5, No. 2, Pages 135-138
    • Malinovsky JM, et al. Le Comité douleur-anesthésie locorégionale de Sfar. [Systemic toxicity of local anaesthetics and lipid emulsions: an interesting supplementary alternative]. Ann Fr Anesth Reanim. 2008 Feb;27(2):132-4
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